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KMID : 1007520140230051637
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Food Science and Biotechnology
2014 Volume.23 No. 5 p.1637 ~ p.1641
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Carpesium abrotanoides Extract Inhibits Inducible Nitric Oxide Synthase Expression Induced by Toll-like Receptor Agonists
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Lee Eun-Kyeong
Jeong Do-Won
Lim Se-Jin
Gu Gyo-Jeong
Ahn Sang-Il
Kim Ji-Soo
Paek Ji-Hun
Kim Song-Mun
Hong Jae-Seung
Lim Soon-Sung
Youn Hyung-Sun
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Abstract
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Inflammation is a pathological and physiological process which is known to be involved in numerous diseases, while it is notable that a considerable proportion of chronic inflammatory diseases overlap with the development of cancer. One of the most important proteins for inflammatory responses is inducible nitric oxide synthase (iNOS). The present study investigated the effect of the extract of Carpesium abrotanoides L. (ECA) on inflammation by modulating iNOS expression induced by toll-like receptors (TLRs) agonists in murine macrophages. ECA suppressed iNOS expression induced by lipopolysaccharide (TLR4 agonist), macrophage-activating lipopeptide 2-kDa (TLR2 and TLR6 agonist), and polyriboinosinic polyribocytidylic acid (TLR3 agonist). All the results suggest that ECA can modulate TLR signaling pathways and subsequent chronic inflammatory responses.
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KEYWORD
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Carpesium abrotanoides, toll-like receptor, inflammation, iNOS, lipopolysaccharide
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